Introducing a new panel to monitor ME/CFS and PASC (post-acute SARS-COV-2).
This panel is designed to identify viral reactivation in patients presenting with chronic fatigue or other post-viral symptoms. This panel utilizes T-cell Elispot testing to identify reactivation of chronic viruses such as EBV and CMV and quantifies 3 key pro-inflammatory cytokines plus serum cortisol. These three pro-inflammatory cytokines (IL-1b, IL-6, TNF-a) have been shown to be elevated in PASC by recent retrospective studies but not reliably elevated in ME/CFS (1,2,3,4). Recent studies show that the timing of the ME/CFS is a better predictor of which cytokines elevate in the course of the disease progression (5). Therefore the search for reactivation versus chronic controlled infection will help the clinician determine treatment protocols specific for the infection and the patient. Clinical signs and symptoms must ultimately be used for diagnosis as there are no definitive diagnostic labs for ME/CFS or PASC according to current CDC guidelines. Utilizing a functional analysis of antigen specific responses to chronic viruses and quantifying the amount of inflammation provides the clinician with tools to assess and treat.